Gleevec Can Act as an Allosteric Activator of ABL Kinase
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چکیده
منابع مشابه
non-protein enzymes: rna can act as an enzyme
within the past few years, neat scheme has been overturned by the discovery that rna can act as an enzyme. what does the starting finding of rna enzymes imply? thre first implication is that one can no longer assume a protein lies behind every catalytic activity of the cell. it now appears that several of the operations that tailor an ran molecule into its final form are at least in part cataly...
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BACKGROUND ABL tyrosine kinases control actin remodeling in development and in response to environmental stimuli. These changes affect cell adhesion, cell migration, and cell-cell contact. Little is known, however, about upstream mechanisms regulating ABL protein activation. RESULTS We report that the RAS effector RIN1 is an activator of ABL tyrosine kinases. RIN1 expression in fibroblasts pr...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.1274